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Developing Next-Generation Activated Protein C for Human Therapeutic Use

ZZ Biotech, LLC - Developing Innovative Biologic Treatments

ZZ Biotech LLC is a clinical stage company developing innovative biologic treatments for ischemic stroke, amyotrophic lateral sclerosis (ALS), other neurological diseases, and wound healing applications including the treatment of diabetic foot ulcers. ZZ Biotech was formed to focus on the development of 3K3A-APC, a novel second-generation variant of a naturally occurring human protein licensed from The Scripps Research Institute.

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THE COMPANY
ZZ Biotech LLC is a clinical stage company developing innovative biologic treatments for ischemic stroke, amyotrophic lateral sclerosis (ALS), other neurological diseases, and diabetic foot ulcers. ZZ Biotech was formed to focus on the development of 3K3A-APC.

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STROKE PROGRAM
ZZ Biotech has completed RHAPSODY, a Phase 2 clinical study in patients with moderate to severe ischemic stroke.

 

 

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ALS PROGRAM
The beneficial mechanisms of APC in treating ALS have been explored, and APC mutants have shown efficacy in rodent models of ALS. A Phase 2 biomarker study in ALS patients is planned for 2020.

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WOUND HEALING PROGRAM
APC and 3K3A-APC have shown efficacy in several in vitro and in vivo wound healing studies. APC has also been studied in multiple human clinical wound healing studies, including a foot ulcer study.