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ZZ Biotech Announces Preliminary Phase 2 Stroke Trial Results with 3K3A-APC

HOUSTON, January 26, 2018—ZZ Biotech today announced that preliminary results of RHAPSODY, the company’s Phase 2 clinical trial in acute ischemic stroke patients, were presented at the 2018 International Stroke Conference in Los Angeles. The placebo-controlled dose-escalation trial was designed to establish a maximally tolerated dose (MTD) of 3K3A-APC in patients with acute ischemic stroke…

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Hope for reversing stroke-induced long-term disability

A human protein combined with stem cell therapy has been found to repair stroke damage to the brain, according to a new USC-led study on mice. Permanent brain damage from a stroke may be reversible thanks to a developing therapeutic technique, a USC-led study has found.

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Stem cell therapy heals injured mouse brain

Animal study examines method for restoring brain cells killed by stroke or other neurological diseases Scientists and clinicians have long dreamed of helping the injured brain repair itself by creating new neurons, and an innovative NIH-funded study published today in Nature Medicine may bring this goal much closer to reality. A team of researchers has…

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ZZ Biotech Acquires Bioatrix

In December 2015, US company ZZ Biotech LLC completed the acquisition of Bioatrix Pty Ltd. Based in Houston, ZZ Biotech is in a Phase 2 trial with 3K3A-Activated Protein C (‘3K3A-APC’) in acute ischemic stroke patients, supported by a grant from the National Institute for Neurological Disease and Stroke. ZZ Biotech’s Australian subsidiary is presently…

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$8 Million NIH Grant Will Fund Multicenter Clinical Trial of Stroke Intervention Drug

Award to Cedars-Sinai Stroke Intervention Researchers Supports Collaborative Study Involving National Institute of Neurological Disorders and Stroke LOS ANGELES (April 22, 2014) – Cedars-Sinai stroke intervention researchers have been informed that the National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, will award an $8 million grant to fund a…

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ZZ Biotech Announces Phase 2 Trial with 3K3A-APC in Stroke

ZZ Biotech Announces Phase 2 Trial with 3K3A-APC in Stroke; Funds Will Be Provided by NIH and Broadview Ventures HOUSTON, April 22, 2014—ZZ Biotech today announced that the National Institutes of Health will support a multicenter Phase 2 clinical trial of its experimental drug, 3K3A-APC, in patients suffering from acute ischemic stroke. The Phase 2…

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Experimental stroke therapeutic developed at Keck Medicine of USC also shows promise for people with Lou Gehrig’s disease (ALS)

New research finds vascular damage in mice with ALS contributes to early development of the neurodegenerative disease, while repairing damage delays disease progression LOS ANGELES, March 3, 2014 — Keck School of Medicine of USC neuroscientists have unlocked a piece of the puzzle in the fight against Lou Gehrig’s disease, a debilitating neurological disorder that…

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Experimental drug reduces brain damage, eliminates brain hemorrhaging in rodents afflicted by stroke

Multi-site phase 2 clinical trials anticipated to begin recruiting patients in 2014 LOS ANGELES, October 24, 2013 — An experimental drug called 3K3A-APC appears to reduce brain damage, eliminate brain hemorrhaging and improve motor skills in older stroke-afflicted mice and stroke-afflicted rats with comorbid conditions such as hypertension, according to a new study from Keck…

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