FOOT ULCER PROGRAM
McKelvey K, Jackson C and Xue M, Activated protein C, a regulator of human skin epidermal keratinocyte functions, World Journal of Biological Chemistry, in press, accepted 18th April 2014.
Miriam T Jackson, Babak Moradi, Margaret M Smith, Christopher J Jackson, and Christopher B Little, Matrix metalloproteinase (MMP)-2, MMP-9 and MMP-13 are activated by Activated Protein C (APC) in human osteoarthritic cartilage chondrocytes. Arthr Rheum, in press, accepted 29th Jan 14.
Shivam Kapila, Ian Reid, Shreya Dixit, Gregory Fulcher, Lynette March, Christopher Jackson, Alan Cooper. The use of dermal injection of Activated Protein C for treatment of large chronic wounds secondary to Pyoderma Gangrenosum. Clinical and Experimental Dermatology, in press, accepted 18th Jan 2014.
Meilang Xue, Kaitlin Shen, Kelly McKelvey Juan Li, Yee-Ka Agnes Chan, Vicky Hatzis, Lyn March, Christopher Little, Michael Tonkin and Christopher J Jackson, Endothelial protein C receptor associated invasiveness of rheumatoid synovial fibroblasts is driven by group V secretory phospholipase A2, Arthritis Research Therapy, in press, accepted 29th Jan 2014.
Xue M and Jackson CJ, Activated Protein C and Its Potential Applications in Prevention of Islet ß-Cell Damage and Diabetes. Vitam Horm. 2014;95:323-63.
S Julovi, K Shen, K McKelvey, N Minhas, L March and C Jackson, APC Inhibits Proliferation and TNFα-stimulated Activation of p38, JNK and Akt in Rheumatoid Synovial Fibroblasts, Mol Med, accepted 14th July, 2013.
Minhas N, Xue M Jackson C. Angiogenic Inhibitors. In: Parnham MJ ed. Encyclopedia of Inflammatory Diseases. Springer. 2013, in press
Whitmont K, McKelvey K, Fulcher G, Reid I, Xue M, Lyn March, Cooper A, Jackson C. Treatment of chronic diabetic lower leg ulcers with activated protein C: a randomised placebo-controlled, double-blind pilot clinical trial. International Wound Journal. Jul 15. doi: 10.1111/iwj.12125. [Epub ahead of print] 2013.
Jackson C, Xue M. Extracellular matrix re-assembly during wound healing and its impact on abnormal scarring. Advances in Wound Care. 2013; in press, accepted Feb 06.
Lee YJ, Jeong JK, Lee JH, Park YG, Moon JH, Seol JW, Jackson CJ, Park SY. Sphingosine-1-phosphate protects against bisphosphonate‑induced HUVEC cell death via regulation of c-Jun‑N‑terminal kinase signaling. Int J Mol Med. 2013 Apr; 31(4):811-6. doi: 10.3892/ijmm.2013.1266. Epub 2013 Feb 4.
Whitmont K, Fulcher G, Reid I, Xue M, McKelvey K, Xie Y, Aboud M, Ward C, Smith MM, Cooper A, March L, Jackson CJ. Low Circulating Protein C Levels Are Associated with Lower Leg Ulcers in Patients with Diabetes. BioMed Research Int. 2013; 2013:Article ID 719570.
Lee YJ, Jeong JK, Seol JW, Xue M Jackson CJ, Park SY. Activated protein C differentially regulates both viability and differentiation of osteoblasts mediated by bisphosphonates. Exp Mol Med. 2013 Feb 15; 45:e9. doi: 10.1038/emm.2013.16.
McKelvey K, Xue M, Whitmont K, Shen K, Cooper A, Jackson C. Potential anti-inflammatory treatments for chronic wounds. Wound Prac and Res. 2012; 20 (2):86-89.
Lay WN, Rayner BS, Sabaretnam T, Figtree GA, Jackson C, Hunyor SN, Bhindi R. Activated protein C improves left ventricular remodelling after ischemia-reperfusion injury in rats. Int J Cardiol. 2012; 159(3):246-8.
Xue M, Dervish S, Harrison LC, Fulcher G, Jackson CJ. Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells and prevents diabetes in NOD mice. J Biol Chem, 2012; 287(20):16356-64.
Downey A, Jackson C, Harun N, Cooper A. Toxic epidermal necrolysis: review of pathogenesis and management. J Am Acad Dermatol. 2012; 66(6):995-1003.
Xue M, Chan YK, Shen K, Dervish S, March L, Sambrook PN, Jackson CJ. Protease-activated receptor 2, rather than protease-activated receptor 1, contributes to the aggressive properties of synovial fibroblasts in rheumatoid arthritis. Arthritis Rheum. 2012; 64(1):88-98.
Jackson CJ, Xue M. Anti-Inflammatory Actions of the Anticoagulant, Activated Protein C. In: Nagal A, ed. Inflammatory Diseases - A Modern Perspective.. ISBN: 978-953-307-444-3, InTech. 2011. Pages 42-74
Julovi SM, Xue M, Dervish S, Sambrook PN, March L, Jackson CJ. Protease activated receptor-2 mediates activated protein C-induced cutaneous wound healing via inhibition of p38, Am J Pathol. 2011; 179(5):2233-42.
Wijewardena A, Vandervord E, Lajevardi SS, Vandervord J, Jackson CJ. Combination of activated protein C and topical negative pressure rapidly regenerates granulation tissue over exposed bone to heal recalcitrant orthopaedic wounds. Int J Low Extrem Wounds. 2011; 10(3):146-51.
Julovi SM, Ito H, Nishitani K, Jackson CJ, Nakamura T. Hyaluronan inhibits matrix metalloproteinase-13 in human arthritic chondrocytes via CD44 and P38. J Orthop Res. 2011; 29:258-64.
Seol JW, Lee YJ, Jackson CJ, Sambrook PN, Park SY. Activated protein C inhibits bisphosphonate-induced endothelial cell death via the endothelial protein C receptor and nuclear factor-κB pathways. Int J Mol Med.2011; 27(6):835-40.
Xue M, Chow SO, Dervish S, Chan YK, Julovi SM, Jackson CJ. Activated protein C enhances human keratinocyte barrier integrity via sequential activation of epidermal growth factor receptor and Tie-2. J Biol Chem. 2011; 286(8):6742-50.
Moon MH, Seol JW, Seo JS, Jeong JK, Lee YJ, Kim IS, Jackson C, Sambrook P, Park SY. Protective effect of hypoxia on bisphosphonate‑related bone cell damage. Mol Med Rep. 2010; 3(5):869-75.
Nguyen TG, Little CB, Yenson VM, Jackson CJ, McCracken SA, Warning J, Stevens V, Gallery EG, Morris JM. Anti-IgD antibody attenuates collagen-induced arthritis by selectively depleting mature B-cells and promoting immune tolerance. J Autoimmun.2010; 35:88-97.
Hunyor SN, Jackson CJ. Microenvironment and macroenvironment in hypertensive hearts: boundaries and silos--can we pick and treat diastolic heart failure? Hypertension. 2010; 55(6):1312-3.
Xue M, Minhas N, Chow SO, Dervish S, Sambrook PN, March L, Jackson CJ. Endogenous protein C is essential for the functional integrity of human endothelial cells. Cell Mol Life Sc. 2010; 67(9):1537-46.
Minhas N, Xue M, Fukudome K, Jackson CJ. Activated protein C utilizes the angiopoietin1/Tie2 axis to promote endothelial barrier function. Faseb J.2010; 24(3):873-81.
Xue ML, Minhas N, Chow SO, Christopher Jackson, Endogenous protein C is essential for the functional integrity of human endothelial cells. Journal of Vascular Research, 2009 46, 39.
Jackson MT, Smith MM, Smith SM, Jackson CJ, Xue M, Little CB. Activation of Cartilage Matrix Metalloproteinases by Activated Protein C. Arthr Rheum. 2009; 60(3):780-91.
Whitmont K, Reid I, Tritton S, March L, Xue M, Lee M, Fulcher G, Sambrook P, Slobedman E, Cooper A, Jackson C. Treatment of chronic leg ulcers with topical activated protein C. Arch Dermatol. 2008; 144(11):1479-83.
Xue M, Jackson CJ. Autocrine actions of matrix metalloproteinase (MMP)-2 counter the effects of MMP-9 to promote survival and prevent terminal differentiation of cultured human keratinocytes. J Invest Dermatol. 2008; 128(11):2676-85.
Jackson C, Whitmont K, Tritton S, March L, Sambrook P, Xue M. New therapeutic applications for the anticoagulant, activated protein C. Expert Opin Biol Ther. 2008; 8(8):1109-22.
Xue M, Smith MM, Little CB, Sambrook P, March L, Jackson CJ. Activated protein C mediates a healing phenotype in cultured tenocytes. J Cell Mol Med. 2009; 13(4):749-757.
Xue A, Scarlett CJ, Jackson CJ, Allen BJ, Smith RC. Prognostic significance of growth factors and the urokinase-type plasminogen activator system in pancreatic ductal adenocarcinoma. Pancreas. 2008; 36:160-167.
Jackson CJ, Xue M. Activated protein C - an anticoagulant that does more than stop clots. Int J Biochem Cell Biol. 2008; 40(12):2692-7.
Jackson C, Whitmont K, Minhas N, et al. A novel wound healing anticoagulant. Wound Repair and Regeneration, 2008, 16, 4, 60.
Xue M, March L, Sambrook PN, Jackson CJ. Differential regulation of matrix metalloproteinase 2 and matrix metalloproteinase 9 by activated protein C: relevance to inflammation in rheumatoid arthritis. Arthr Rheum. 2007; 56(9):2864-74. PMID: 17763449
Wang Y, Chang HI, Wertheim DF, Jones AS, Jackson C, Coombes AG. Characterisation of the macroporosity of polycaprolactone-based biocomposites and release kinetics for drug delivery. Biomaterials. 2007; 28(31):4619-27.
Xie L, Galettis A, Morris J, Jackson C, Twigg SM, Gallery ED. Intercellular adhesion molecule-1 (ICAM-1) expression is necessary for monocyte adhesion to the placental bed endothelium and is increased in type 1 diabetic human pregnancy. Diabetes Metab Res Rev. 2008; 24(4):294-300.
Xue M, March L, Sambrook PN, Fukudome K, Jackson CJ. Endothelial protein C receptor is overexpressed in rheumatoid arthritic (RA) synovium and mediates the anti-inflammatory effects of activated protein C in RA monocytes. Ann Rheum Dis, 2007; 66(12):1574-80.
Xue M, Campbell D, Jackson CJ. Protein C is an autocrine growth factor for human skin keratinocytes. J Biol Chem. 200; 282(18):13610-6.
Gallagher GL, Jackson CJ, Hunyor SN. Myocardial extracellular matrix remodeling in ischemic heart failure. Front Biosci. 2007; 12:1410-19.
Gallagher G, Menzie S, Huang Y, Jackson C, Hunyor SN. Regional cardiac dysfunction is associated with specific alterations in inflammatory cytokines and matrix metalloproteinases after acute myocardial infarction. Basic Res Cardiology. 2007; 102(1):63-72.
Jackson C, March L, Sambrook P Endothelial protein C receptor is over-expressed in rheumatoid arthritic (RA) synovium and mediates the anti-inflammatory effects of activated protein C, Inflammation Research, 56, 477.
Jackson CJ, Xue M. Activated protein C (APC) as a novel agent to promote wound healing. Primary Intention. 2006; 14(1):31-34.
Xue M, Le NT, Jackson CJ. Targeting matrix metalloproteases to improve cutaneous wound healing. Exp Opin Ther Targets. 2006; 10(1): 143-155.
Xue M, Thompson P, Sambrook PN, March L, Jackson CJ. Activated protein C stimulates expression of angiogenic factors in human skin cells, angiogenesis in the chick embryo and cutaneous wound healing in rodents. Clin Hemorheol Micro. 2006; 34 (1-2): 155-161.
Xue M, Campbell D, Sambrook PN, Fukudome K, Jackson CJ. Endothelial protein C receptor and protease activated receptor-1 mediate induction of a wound healing phenotype in human keratinocytes by activated protein C. J Invest Derm. 2005; 125: 1279-85.
Xue ML, Campbell D, March L and C. Jackson. Activated protein C attenuates the production of matrix metalloproteinase-9 in monocytes from rheumatoid arthritic patients via endothelial protein C receptor and inhibition of NF-kB, Inflammation Research, 54, 2005, S118.
Jackson CJ, Xue M, Thompson P, Davey RA, Whitmont K, Smith S, Buisson-Legendre N, Sztynda T, Furphy LJ, Cooper A, Sambrook P, March L. Activated protein C stimulates angiogenesis and prevents inflammation to promote cutaneous wound healing. Wound Repair Regen. 2005; 13: 284-294.